Cardiovascular
• Heart attack (acute coronary syndrome)
• Heart failure
• Stroke
• Shock (e.g., cardiogenic, septic)
• Cardiac arrest
• Severe bleeding
Respiratory
• Respiratory failure
• Acute Respiratory Distress Syndrome (ARDS)
• Pneumonia
• Pulmonary embolism
Infectious and Systemic
• Sepsis
• Severe infections
• Septic shock
• Drug overdose
• Severe influenza
Trauma and Injury
• Severe trauma and injuries (e.g., car crashes, falls)
• Traumatic brain injury (TBI)
• Severe burns
• Major head trauma
Organ and Metabolic
• Acute kidney injury or kidney failure
• Acute liver failure
• Acute pancreatitis
• Multiple organ failure
• Metabolic disorders